Thierry Passeron,Elodie Le Pape,Gian Marco De Donatis
申请号：
US14914928
公开号：
US20160208249A1
申请日:
2014.09.03
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention relates to nucleic acid sequences as well as to modified oligonucleotides (ODNs) comprising a p52 binding site derived from the EZH2 promoter region, as well as to compositions and methods for treating cancer. The invention relates to peptides derived from p52 as well as to compositions and methods for treating cancer. The invention also provides compositions and methods for inducing senescence in cancer cells (e.g. in epithelial cancer cells). The invention also provides compositions and methods for inhibiting expression of EZH2 in cancer cells. The invention further provides a new combination therapy as well as compositions and thereof for treating cancer.
