Transcription factor modulating compounds and methods of use thereof农业专利-农业学术服务平台

发明人:: レビースチュアートビー．,アレクシュンミッシェルエヌ．,ポドロガーブレント,オーメングクワシ,ベルマアチュル,ワーコルタデウシュ,バティアビーナ,レビースチュアートビー.,アレクシュンミッシェルエヌ.

摘要：: Methods for identifying compound useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. In one embodiment, the method comprises contacting a microbial cell comprising: 1) a selectable marker under the control of a transcription factor responsive element and 2) a transcription factor, with a compound under conditions which allow interaction of the compound with the microbial cell； and measuring the ability of the compound to affect the growth or survival of the microbial cell as an indication of whether the test compound modulates the activity of a transcription factor.