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Bruton Tyrosine Kinase Inhibitors, Treatment Method, Compound, combination, Formulation
- 专利权人:
- F. HOFFMANN-LA ROCHE AG
- 发明人:
- RAMAN MAHADEVAN IYER,DRAMANE IBRAHIM LAINE,FRANCISCO JAVIER LOPEZ-TAPIA,JONATHAN E. PHILLIPS,CHRISTOPHER STEVENSON
- 申请号：
- ARP130104376
- 公开号：
- AR093635A1
- 申请日:
- 2013.11.28
- 申请国别(地区):
- AR
- 年份:
- 2015
- 代理人:
- 摘要：
- Method of treatment or improvement for asthma comprising administering by inhalation of inhibitors of Btk 6-tert-butyl-8-fluoro-2- {3-hydroxymethyl-4- [1-methyl-5- (1-methyl-1, 2,3,4,5,6-hexahydro- [3,4] bipyridinyl-6-ylamino) -6-oxo-1,6-dihydro-pyridazin-3-yl] -pyridin-2-yl} -2H- phthalazin-1-one, 2- (2- {3- [5- (5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino) -1-methyl-6-oxo-1,6 -dihydro-pyridazin-3-yl] -2-hydroxymethyl-phenyl} -8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl) -2-methyl-propionitrile and 6-tert-butyl- 2- [2-hydroxymethyl-3- (5- {5 - [(2-methoxy-ethylamino) -methyl] -pyridin-2-ylamino} -6-oxo-1,6-dihydro-pyridin-3-yl) -phenyl] -3,4-dihydro-2H-isoquinolin-1-one, formulations thereof,and methods of asthma treatment, as indicated herein. Claim 3: Formulation comprising 6-tert-butyl-8-fluoro-2- {3-hydroxymethyl-4- [1-methyl-5- (1-methyl-1,2,3,4,5,6-hexahydro - [3,4] bipyridinyl-6-ylamino) -6-oxo-1,6-dihydro-pyridazin-3-yl] -pyridin-2-yl} -2H-micronized phthalazin-1-one and micronized lactose. Claim 6: Formulation comprising 2- (2-3- [5- (5-azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino) -1-methyl-6-oxo-1,6- gave-2-hydroxymethylphenyl} - 8-fluoro-1-oxo-1, 2-dihydro-isoquinlin-6-il-2-methyl-propyl nitric acid and lactose. 11. Claim 9: comprising 6-tributyl-2 - [2-hydroxy-3 - (5 - [(2-methoxy-ethylamine) - methyl] - pyridine-2-ethylamine} - 6-oxo-1, 6-dihydro-pyridin-3-il) - phenyl] - 3, 4-dihydro-2h-isoquinine-1-picimilarization and lactification. 11. Requirement 12: compound (1)Or acceptable saltMétodo de tratamiento o mejora para el asma que comprende administrar mediante inhalación de inhibidores de Btk 6-terc-butil-8-fluoro-2-{3-hidroximetil-4-[1-metil-5-(1-metil-1,2,3,4,5,6-hexahidro-[3,4]bipiridinil-6-ilamino)-6-oxo-1,6-dihidro-piridazin-3-il]-piridin-2-il}-2H-ftalazin-1-ona, 2-(2-{3-[5-(5-azetidin-1-ilmetil-1-metil-1H-pirazol-3-ilamino)-1-metil-6-oxo-1,6-dihidro-piridazin-3-il]-2-hidroximetil-fenil}-8-fluoro-1-oxo-1,2-dihidro-isoquinolin-6-il)
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
