The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular , the method relates to a cancer treatment method that includes administering 2- [(5 - Chloro- 2 - { [3- methyl - 1 -(1- methylethy 1)- 1Z/- pyrazol -5 - yl] amino } - 4 -pyridinyl)amino] -iV-(methyloxy)benzamide , or a pharmaceutically acceptable salt thereof , and N- { 3 - [3 -cyclopropyl -5 -(2 -fluoro- 4 -iodo- henylammo)6, 8- dimethyl- 2, 4, 7- trioxo- 3, 4 ,6 ,7- te trahydro- 2H- pyrido[4, 3- d]pyrimidin - 1 - yl]phenyl} acetamide, or a pharmaceutically acceptable salt or solvate thereof , to a human in need thereof.
