Merrill BIEL,Lewis R. MAKINGS,Roger HEIM,Miguel GARCIA-GUZMAN,Eileen Sun CHIN,Deepak YADAV,Jerry FONG
申请号：
US15753153
公开号：
US20180250405A1
申请日:
2016.08.18
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are conjugates, compositions and methods for use in photoimmunotherapy, such as photoimmunotherapy induced by activation of a phthalocyanine dye conjugated to a targeting molecule that binds a protein on cell, for example, an IR700-antibody conjugate. In some embodiments, the phthalocyanine-dye conjugate can be activated by irradiation with near-infrared light. Features of the conjugates, compositions and methods, including the dose of the conjugate, provide various advantages, such as lower toxicity and/or improved efficacy. In some embodiments, also provided is a dual label phthalocyanine-dye conjugate in which the targeting molecule is conjugated to an additional fluorescent dye, which can be used for photoimmunotherapy while, for example, also exhibiting improved performance for imaging or detection. Also provided are therapeutic methods using the conjugates and compositions for treatment of diseases and conditions, including tumors or cancers.
