A therapy regimen is described for the treatment of severe acne related diseases preferentially severe or nodular acne. The therapy regimen adds a topical fixed-dose combination of a retinoid and an anti-bacterial agent, such as benzoyl peroxide, to a course of oral antibiotic therapy using a daily dose of antibiotic ranging from 150 mg to 300 mg per day.Also described, is a fixed-dose combination of a retinoid and an anti-bacterial agent for use in the therapy regimen, and a kit suitable for implementing such therapy.
