METHODS FOR TREATING AND/OR PREVENTING A TUMOR GROWTH, INVASION AND/OR METASTASIS

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专利权人:

发明人:

HUIE LEE,YU-JU HUANG

申请号：

US15518088

公开号：

US20180265874A1

申请日:

2015.10.09

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The invention relates to a method for treating and/or preventing a tumor growth, invasion and/or metastasis by inhibiting an overexpression of PD-L1 in the subject via an autocrine loop. The invention found that PD-L1-modulated p21 and VEGF-C expression via the TGFβ1/SMAD4 pathway is responsible for the cancer growth, invasion and metastasis.

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中国工程科技知识中心

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