The present invention relates to the use ofParapoxvirus ovisin combination with at least one additional anti-cancer agent for the preparation of a medicament for treating cancer. The invention furthermore relates to the use ofParapoxvirus ovisfor the production of a medicament for treating cancer in combination with at least one additional anti-cancer agent.本發明有關於一種副痘病毒結合至少一外加抗癌劑於製備用以治療癌症的一藥物之用途。本發明進一步關於用以製造治療癌症之一藥物的一副痘病毒結合至少一外加抗癌劑之用途。