The present invention relates to combination vaccines and methods for treating or preventing diseases or disorders in an animal caused by infection by one or more of the following : Bovine Viral Diarrhea Virus (BVDV) Types 1 and 2, Leptospira hardjo-bovis and Leptospira pomona by administering to the animal an effective amount of a combination vaccine. The combination vaccine can be a whole or partial cell inactivated or modified live preparation.