A nebulization system includes a power adapter and a nebulizer. The nebulizer includes a nebulization module and a nebulization driving device. The nebulization driving device includes a battery unit, an input terminal, a voltage detection unit, a voltage adjustment unit, a control unit, and a driving unit. The input terminal is coupled to the power adapter and the battery unit. The voltage detection unit detects whether the input voltage of the input terminal is larger than a predefined value. When the input voltage is larger than the predefined value, the control unit controls the voltage adjustment unit to adjust the input voltage to a first operating voltage and then to output it. When the input voltage is smaller than the predefined value, the control unit controls the voltage adjustment unit to adjust the input voltage to a second operating voltage and then to output it, wherein the first voltage is larger than the second voltage. The driving unit drives the nebulization module to generate spray in accordance with the output voltage of the voltage adjustment unit.一種霧化系統包括電源適配器以及霧化器。霧化器包括霧化模組及霧化驅動裝置。霧化驅動裝置包括電池單元、輸入端、電壓偵測單元、電壓調整單元、控制單元及驅動單元。輸入端耦接電源適配器及電池單元。電壓偵測單元偵測輸入端的輸入電壓是否大於設定值。當輸入電壓大於設定值時,控制單元控制電壓調整單元將輸入電壓調整至第一工作電壓而輸出,而當輸入電壓小於設定值時,控制單元控制電壓調整單元將輸入電壓調整至第二工作電壓而輸出,其中第一工作電壓大於第二工作電壓。驅動單元依據電壓調整單元的輸出電壓驅動霧化模組產生噴霧。