DESARBRE ERIC,GAUCHER BERANGERE,PAGE MALCOLM G. P.,ROUSSEL PATRICK
申请号：
SI200631200
公开号：
SI1965798T1
申请日:
2006.12.07
申请国别(地区):
SI
年份:
2012
代理人:
摘要：
Compounds of the formula II: in which R8 is of the formula Q-(X) r -CO- wherein either a) X = - CH 2 -, r = 1, Q is a pyridinium group and R7 is -SO 3 - or -OSO 3 - or b) X = -SCH 2 - and r = 1 wherein Q is e.g. 1,2,3,4-tetrazol-5-yl and R7 is -SO 3 H or -OSO 3 H or c) X = -CH 2 NH 2 -, r = 1 and Q is e.g. phenyl or a 5-6-membered heterocycle and R7 is -SO 3 H or -OSO 3 H or d) X = -NH 2 - and r = 1, wherein Q is e.g. phenyl and R7 is - SO 3 H or -OSO 3 H are beta-lactamase inhibitors. They may be used in combination with monobactams against gram-negative bacteria.
