n- (4-hydroxy-4-methylcyclohexyl) -4-phenylbenzenesulfonamides and n- (4-hydroxy-4-methylcyclohexyl) -4- (2-pyridyl) benzenesulfonamides and their therapeutic uses
IAIN ROBERT GREIG,LISA PATEL,SAMUEL CAMERON WILLIAMS,STEPHEN ALLAN SMITH
申请号：
BR112015031527
公开号：
BR112015031527A2
申请日:
2014.06.24
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention relates to therapeutic compounds. specifically, n- (4-hydroxy-4-methylcyclohexyl) -4-phenylbenzenesulfonamide and n- (4-hydroxy-4-methylcyclohexyl) -4- (2-pyridyl) benzenesulfonamide compounds substituted (hmc compounds) useful, for example, in the treatment of disorders such as inflammation, joint destruction, bone loss； disorder mediated by excessive, inappropriate, prolonged activation of the immune system； inflammatory and autoimmune disorders, for example rheumatoid arthritis； psoriasis； psoriatic arthritis； copd； asthma； atherosclerosis； inflammatory bowel disease； ankylosing spondylitis； multiple sclerosis； systemic lupus erythematosus； sjogren's syndrome； bone loss disorder, such as that associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, or paget disease； cancer, such as hematologic malignancy, such as multiple myeloma, leukemia or lymphoma, or solid tumor cancer, such as bladder, breast (female / male), colon, renal cell carcinoma, kidney, lung, pancreatic cancer, gastric, prostate, brain, skin, thyroid, basal cell ameloblastoma, or melanoma； fibrosis-associated disorder such as systemic sclerosis or scleroderma； or rare vasculitide, such as behçet's disease. further relates to pharmaceutical compositions with such compounds, and their use, for example, in therapy.a presente invenção refere-se a compostos terapêuticos. especificamente, compostos de n-(4-hidróxi-4-metil-ciclo-hexil)-4-fenil-benzenossulfonamida e n-(4-hidróxi-4-metil-ciclo-hexil)-4-(2-piridil)benzenossulfonamida substituídos (compostos de hmc) úteis, por exemplo, no tratamento de distúrbios como inflamação, destruição de articulações, perda óssea； distúrbio mediado por ativação excessiva, inapropriada, prolongada do sistema imune； distúrbios inflamatórios e autoimunes, por exemplo, artrite reumatoide； psoríase； artrite psoriática； copd； asma； aterosclerose； doença inflamatória do intestino； espondilite anq
