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Formulation based on polyphosphate microparticles for topical treatment of difficult-to-heal wounds
专利权人:
NanotecMARIN GmbH
发明人:
Werner Ernst Ludwig Georg Mueller
申请号:
GB201701403
公开号:
GB2559163A
申请日:
2017.01.27
申请国别(地区):
GB
年份:
2018
代理人:
摘要:
A formulation having wound healing properties, such as an acceleration of wound healing, comprises amorphous microparticles or nanoparticles of a salt of polyphosphate and a divalent cation, preferably calcium or magnesium. The salt may be formed by adding a solution of a salt of a divalent cation to an aqueous sodium polyphosphate solution, which has been adjusted to pH 10.0 through the addition of an alkali, such as sodium hydroxide. The formed particles may be stirred overnight and collected by filtration. Preferably the formulation also comprises an alginate or collagen. A wound dressing may comprise the nanoparticles or microparticles embedded in an electrospun meshwork consisting of polylactide (or its copolymers), polycaprolactone (or its copolymers), or another biocompatible polymer. The formulation may alternatively be provided as a powder or gel. Preferably, the formulation is used in the treatment of wounds in patients showing delayed wound healing, such as in the elderly, or diabetic patients.
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中国工程科技知识中心
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