Chandrashekar K. Tavarekere;Sivakumari Asha Nair;Danaboyina Ramaiah;Madhavan Radhakrishna Pillai;Mohan Chintalagi;Saneesh Babu P. Saras;Srinivasan Alagar;Suneesh C. Karunakaran;Jisha S. Vadakkancheril
发明人:
Danaboyina Ramaiah,Suneesh C. Karunakaran,Jisha S. Vadakkancheril,Chandrashekar K. Tavarekere,Srinivasan Alagar,Madhavan Radhakrishna Pillai,Sivakumari Asha Nair,Saneesh Babu P. Saras,Mohan Chintalagi
申请号：
US13574512
公开号：
US20120308485A1
申请日:
2011.01.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides novel porphyrin derivatives represented by the general formula 1 and/or pharmaceutically acceptable derivatives thereof as NIR sensitizers for photodynamic therapeutic and diagnostic, biological and industrial applications. These porphyrin derivatives posses absorption (400-700 nm) and emission (600-750 nm) in the regions where biological chromophores do not absorb and hence are ideal candidates for application as NIR PDT agents and fluorescence sensors for medicinal applications in biology. The substituents like hydroxyl and glycolic units on these dyes render them amphiphilicity thereby improving their solubility in the aqueous media and cellular uptake and localization. These dyes show no toxicity in the dark and are highly selective towards tumor cells and stain nucleus very rapidly. Accordingly, these porphyrin derivatives are extremely useful as NIR PDT fluorescence sensors in photodynamic therapeutic and diagnostic, biological and industrial applications.
