Joseph Gabriele,David Baranowski,Beth Buchanan,Jonathan Zuccolo,Mikaela Teris
申请号：
US15752900
公开号：
US20180235870A1
申请日:
2016.08.17
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present application is directed to transdermal formulations for the delivery of berberine compounds to a subject for the treatment of berberine-responsive diseases. In particular, the transdermal formulation comprises: (a) an aqueous phase comprising water and at least one water soluble emulsion stabilizer； (b) an oil phase comprising at least one emulsifier, at least one oil soluble emulsion stabilizer, at least one emollient comprising at least one flavonoid and at least one other emollient； wherein the oil and aqueous phases form an emulsion； (c) an external phase comprising at least one flavonoid containing-extract, at least one phospholipid-complexed flavonoid and at least one source of berberine or analog or derivative thereof； and optionally (d) at least one preservative phase.
