Refill and dosage management devices and associated systems and methods for use with computerized oral prescription administration (COPA) devices are provided. In one embodiment, an apparatus includes a housing having a structure sized and shaped to receive at least a portion of a mouthpiece of an intended user； and a dispensing unit coupled to the housing, the dispensing unit configured to dispense a substance into a reservoir of the mouthpiece. In another embodiment, a method includes receiving, by a docking station, at least a portion of a mouthpiece of an intended user； and dispensing, by a dispensing unit coupled to the docking station, a substance into a reservoir of the mouthpiece.
