Deqiang AN,Nianhe HAN,Di ZENG,Hang YANG,Peng ZHU,Mingzhen LI,Li JIAN,Chun YANG
申请号：
US14807234
公开号：
US20160015832A1
申请日:
2015.07.23
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed are a type of tridentate linkers and use thereof. The tridentate linkers can be used to prepare an antibody drug conjugates as represented by formula I,L-(T-A-D)n Iwherein, L is an antibody, antibody fragment or protein； T is a tridentate linker part； A is a cleavable linker group or a noncleavable linker part； D is a drug part； n is an integer of 0-8. The structure of the tridentate linker part is as represented by formula II.wherein, W is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or any combination thereof.
