Johan Auwerx,Richardus Houtkooper,Laurent Mouchiroud
申请号：
US14239198
公开号：
US20140187611A1
申请日:
2012.08.20
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrial disease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including inhibiting the mitochondrial translation machinery function, as well as methods for screening agents that are able to increase lifespan, inhibit or delay aging, and/or prevent or treat an age-related disease or disorder, or a mitochondrial disease or disorder, in a subject.
