HUANG, CHI HUNG,黄济鸿,黃濟鴻,HSIEH, SHU JU,谢淑如,謝淑如,YANG, CHIA SHIN,杨佳昕,楊佳昕,CHEN, SUNG YUAN,陈松远,陳松遠,SU, YU ZHEN,苏昱祯,蘇昱禎
申请号：
TW108106827
公开号：
TW202031676A
申请日:
2019.02.27
申请国别(地区):
TW
年份:
2020
代理人:
摘要：
The present disclosure relates to the mutated recombinant HOXB4 proteins, including at least one mutation at three specific positions within the DNA binding domain. The mutation enhances DNA binding ability and potency of inducing hematopoietic stem cell expansion compared to wild type HOXB4.本發明係關於突變型HOXB4重組蛋白質，其突變點在於去氧核醣核酸結合區域內三個特定位置，其相較於野生型之HOXB4，具有相當或較高的DNA結合能力及促進造血幹細胞增生之效果。
