MICROBILLE BIODÉGRADABLE COMPRENANT UN POLYMÈRE ANIONIQUE POUR AMÉLIORER LA CAPACITÉ D'ADSORPTION DE MÉDICAMENTS ANTICANCÉREUX, ET PROCÉDÉ DE PRÉPARATION DE CELLE-CI
UTAH-INHA DDS & ADVANCED THERAPEUTICS RESEARCH CENTER
发明人:
KIM, SE YOON,LEE, DON HAENG,YANG, SU-GEUN
申请号：
EP13858512
公开号：
EP2926806A4
申请日:
2013.11.15
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The present invention relates to a biodegradable microbead having improved adsorptive power to anticancer drugs, to a method for preparing same, and to a method for treating cancer using same. According to the present invention, a rigid bead having excellent adsorptive power to anticancer drugs can be prepared through cross-linking and an amide bond between an albumin and an anionic polymer. Also, the microbead of the present invention is prepared by a biocompatible and biodegradable polymer so as to be safe when applied to the human body. Further, the microbead of the present invention can effectively inhibit the growth of a tumor by effectively blocking a blood vessel which supplies nutrients to a liver tumor, while continuously releasing anticancer drugs which are adsorbed into the surface of the bead. Thus, the present invention can be usefully applied to a chemoembolization of liver cancer.
