The present invention, in one or more embodiments, including derivative (elegant jessamine 3-n-pentadecylcatechol laccols are saturated homologue) and/or 3-n-heptadecyl catechols (malicious oak laccol is saturated homologue) are used to prevent as composition and/or prophylactic treatment contact dermatitis is by toxicodendron and malicious oak. Present invention is alternatively directed to the preparation methods of such compound. Disclose compound, these compounds have tolerance and the subject that desensitizes is directed to contained in the Anacardiaceae plant of anaphylactogen and Ginkgoaceae family includes the mammal of laccol ester [general formula (IA) should enter here] immune tolerence induced cell and desensitization, including the mankind, contained in the Anacardiaceae plant to anaphylactogen and the acquisition preparation administration of Ginkgoaceae family is by containing at least one laccol ester compounds.
