It is intended to provide an antibody which inhibits the function of midkine. An antibody which recognizes an epitope consisting of amino acid residues 62 to 104 of midkine or a fragment thereof； DNA encoding the antibody or a fragment thereof； a recombinant vector which contains the DNA； a transformant which has the vector or a hybridoma which produces the antibody； a method for producing the antibody by allowing the transformant or hybridoma to produce the antibody or a fragment thereof and collecting the resulting antibody or fragment thereof； a pharmaceutical composition containing the antibody or a fragment thereof as an active ingredient； and a diagnostic agent containing the antibody or a fragment thereof as an active ingredient.
