One aspect of the present disclosure relates to a method for treating a circadian rhythm disorder in a mammal. One step of the method includes placing a therapy delivery device into electrical communication with an autonomic nervous system (ANS) nerve target associated with the circadian rhythm disorder. Next, the therapy delivery device is activated to deliver a therapy signal to the ANS nerve target in an amount and for a time sufficient to effect a change in sympathetic and/or parasympathetic activity in the mammal and thereby treat the circadian rhythm disorder.