#$%^&*AU2014268219A120141218.pdf#####ABSTRACT This invention discloses compositions and methods for inducing, promoting or otherwise facilitating pain relief. More particularly, the present invention discloses the use of sub-normovasodilatory doses of furoxan-containing nitric oxide donors in the 5 therapeutic management of vertebrate animals including humans, for the prevention or alleviation of pain, especially neuropathic pain. According to some embodiments of the present invention, furoxan-containing nitric oxide donors are administered by any suitable route so as to provide concentrations of NO that are about to 10-5 of those known to induce vasodilation in normal circulations.