ALESSI, THOMAS R,MERCER, RYAN D,ROHLOFF, CATHERINE M,YANG, BING
申请号:
NZ59211309
公开号:
NZ592113A
申请日:
2009.10.14
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a pharmaceutical suspension formulation comprising, a particle formulation comprising, about 25 wt percent to about 80 wt percent drug, wherein the drug is a protein, and about 75 wt percent to about 20 wt percent of one or more additional component, wherein the one or more additional component comprises antioxidant e.g. methionine, carbohydrate e.g. sucrose, and buffer e.g. citrate, and the ratio of drug:antioxidant:carbohydrate:buffer is between about 2-20: 1-5: 1-5: 1-10; and a non-aqueous, single-phase suspension vehicle comprising one or more polymer and one or more solvent.