PROCESS FOR MAKING CRYSTALLINE FORM A OF GEFITINIB

• 收藏
• 分享

专利权人:

发明人:

申请号：

EP16820268.7

公开号：

EP3397618A1

申请日:

2016.12.22

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention relates to for it is characterized in that an XRPD powder diffraction pattern formula (1) Gefitinib crystalline form 1 preparation method, comprising: especially about 7.14,11.26,14.25,15.86,24.33 and 26.40 degree of 2 θ (+- 0.2 degree of 2 θ), process reaches high point and comprises the steps of 1.In the molten Gefitinib that disappears that a kind of solvent mixture includes in form ethanol and butanol selected by water and an alcohol, wherein the ratio between water and alcohol is between 1: 16 and 1: 25 (volume: volume) 2. Isolated Gefitinib table 1.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/