PROF. DR. FAUZIAH OTHMAN,PROF. DR. ASMAH RAHMAT,DR. IDRIS BESAR,RUSNAH MUSTAFFA
申请号：
MYPI 20085327
公开号：
MY145774A
申请日:
2008.12.26
申请国别(地区):
MY
年份:
2012
代理人:
摘要：
THE POROUS HYDROXYAPATITE (HA) BIOMATERIAL HAS BEEN EXAMINED FOR ITS SURFACE MORPHOLOGY. IT IS IRREGULAR SHAPE CHIPS OF 2-3MM. HOWEVER, THE PORE SIZE IS BETWEEN 150-350 µM, WHICH INCLUDED MICROPORES AND MICROPORES, WHILE THE POROSITY IS BETWEEN 65-70%. WHEN PLACED IN CONTACT WITH VIABLE BONE, NEW BONE FOHNS ON AND BETWEEN THE PORES OF HA. THEREFORE, THE MICROPORES HAVE BEEN COVERED WHEN LOADED IN GENTAMYCIN SOLUTION THROUGH THE IMAGES OF GENTAMYCIN-LOADED HA UNDER SCANNING ELECTRON MICROSCOPE (SEM). HA WAS BIOCOMPATIBLE WITH OSTEOBLAST BY TESTING WITH MTT ASSAY. THERE WAS NO SIGNIFICANCE OF IC50 GENTAMYCIN AT THE, PERCENTAGE OF VIABILITY CELL WAS HIGH. IN THE WORDS, THERE WAS SIGNIFICANCE OF IC50 OF GENTAMYCIN WHICH WAS O.3MG/ML AFTER TREATMENT. THE PERCENTAGE OF VIABILITY OF BIOFILM DROPPED. THE HIGHER CONCENTRATION OF GENTAMYCIN HAD BEEN LOADED, THE LOWER OF VIABLE BIOFILM PERCENTAGE. THUS, THE RESULTS INDICATED THAT THE GENTAMYCIN-IOADED HA HAD THE ABILITY TO REDUCE OR ERADICATE THE BIOFILM FORMATION WHICH FORMED ON THE IMPLANT DEVICES.
