GURNEY, Austin,YEN, Wan-Ching,HOEY, Timothy Charles
申请号：
USUS2015/063480
公开号：
WO2016/090024A4
申请日:
2015.12.02
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
Described herein are combination therapies for the treatment of cancer and other diseases. In one aspect, the methods described herein for the treatment of cancer and other diseases comprise administering a RSPO-LGR pathway inhibitor in combination with a mitotic inhibitor. The present invention relates to methods of treating cancer comprising administering to a subject a therapeutically effective amount of an RSPO-LGR pathway inhibitor, such as an antiRSP03 antibody or anti-LGR5 antibody. In certain embodiments, the methods further comprise administration of a mitotic inhibitor to the patient. In certain embodiments the RSPO-LGR pathway inhibitor is administered about 1 day, about 2 days, or about 3 days prior to the mitotic inhibitor.Linvention concerne des polythérapies pour le traitement du cancer et dautres maladies. Dans un aspect, les procédés décrits pour le traitement du cancer et dautres maladies comprennent ladministration dun inhibiteur de la voie LGR-RSPO en combinaison avec un inhibiteur mitotique.
