Christopher D. BARRETT,Michael B. YAFFE,Ernest E. MOORE,Hunter B. MOORE,Michael P. CHAPMAN
申请号：
US16630384
公开号：
US20200129448A1
申请日:
2018.07.13
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The current disclosure provides compositions and methods for wound closure. The disclosure provides an device comprising: a) a material with a surface comprising a modified fibrinogen or a modified fibrin, wherein the modified fibrinogen or modified fibrin is more resistant to fibrinolysis than an unmodified fibrinogen or an unmodified fibrin, respectively； and b) one or more dispersible fibrinolysis inhibitors in contact with the surface comprising a plasmin inhibitor； and c) optionally, a thrombin agent or platelets.
