FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARAÑON
发明人:
TEJEDOR JORGE, ALBERTO,LAZARO FERNANDEZ, ALBERTO,CAMANO PAEZ, SONIA,TORRES REDONDO, ANA MARÍA,LAZARO MANERO, JOSÉ ANTONIO,CASTILLA BARBA, MANUELA,DE LUCAS COLLANTES, MARÍA DEL CARMEN
申请号：
DK09164710
公开号：
DK2143429T5
申请日:
2009.07.07
申请国别(地区):
DK
年份:
2014
代理人:
摘要：
Use of cilastatin to reduce the nephrotoxicity of different compounds. The invention refers to use of cilastatin to prepare a medicinal product to reduce the nephrotoxicity of a nephrotoxic compound that enters the cells of the proximal tubule through cholesterol rafts. The invention is based on the discovery that a great number of nephrotoxic compounds, including drugs, enter the cells of the proximal tubule through the cholesterol rafts, and that cilastatin is able to interfere with this transport mechanism, decreasing the nephrotoxicity of such compounds to a variable extent. The nephroprotective effect is common to compounds of different chemical nature and solubility and is specific for the kidney, causing no interference with the effects of nephrotoxic drugs having their targets in other organs. Therefore, administration of cilastatin allows for decreasing the nephrotoxic effects of different drugs without reducing their therapeutic effects.
