A use of pharmaceutical composition for manufacturing drug of treating betel quid use disorder is disclosed. The pharmaceutical composition includes an effective amount of an anti-depressant. Accordingly, the betel quid use disorder of a patient will be improved, and an incidence of oral cavity cancer can be indirectly reduced.本發明提供一種醫藥組合物用於製備治療檳榔使用失調之藥物上的用途。前述醫藥組合物至少包含一有效劑量之抗憂鬱劑,藉此可有效改善患者之檳榔使用失調情況,進而間接降低口腔癌的發生率。S100、S102、S104、S106‧‧‧步驟