Anti-Tweak antibodies are described. The anti-Tweak antibodies bind to anepitope on human TWEAK that overlaps with the epitope bound by P2D10, huP2D10-1, orhuP2D10-2 or have heavy and/or light chain variable domain sequences that arestructurallyanalogous to those of P2D10, huP2D10-1, or huP2D10-2.