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Compositions to treat drug addiction and improve addiction-related behavior
专利权人:
Ltd.;SK Biopharmaceuticals Co.
发明人:
LEE, Sung James,MELNICK, Susan
申请号:
ES10792277
公开号:
ES2766272T3
申请日:
2010.06.10
申请国别(地区):
ES
年份:
2020
代理人:
摘要:
A composition for use in the treatment of a drug addiction comprising a therapeutically effective amount of a carbamate compound, or a pharmaceutically acceptable salt or ester thereof, as an active ingredient, wherein the addictive drug is cocaine, and wherein the compound of carbamate is selected from the group consisting of the carbamate compound having structural Formula (1) ** Formula ** wherein, R is selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, selected halogen of F, Cl, Br and I, alkoxy of 1 to 3 carbon atoms, nitro group, hydroxy, trifluoromethyl, and thioalkoxy of 1 to 3 carbon atoms, x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3, R1 and R2 may be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, or cycloalkyl of 3 to 7 atoms carbon, and R1 and R2 can n join together to form a 5 to 7 membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl and aryl groups, wherein the heterocyclic compound comprises 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms, and the nitrogen atoms are not directly connected to each other or to the oxygen atom; and the compounds represented by the following structures: ** Formula **Una composición para uso en el tratamiento de una drogadicción que comprende una cantidad terapéuticamente eficaz de un compuesto de carbamato, o una sal o éster farmacéuticamente aceptable del mismo, como principio activo, en donde la droga adictiva es cocaína, y en donde el compuesto de carbamato se selecciona del grupo que consiste en el compuesto de carbamato que tiene la Fórmula estructural (1)**Fórmula** en donde, R se selecciona del grupo que consiste en hidrógeno, alquilo inferior de 1 a 8 átomos de carbono, halógeno seleccionado de F, Cl, Br y I, alcoxi de 1 a 3 átomos de carbono, grupo nitro, hidroxi, trifluorometilo, y tioalc
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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