#$%^&*AU2013203609B220140821.pdf#####32 ABSTRACT Provided are a method for screening a drug which is efficacious in treating dry eye with a dry eye severity 5 level 3 or higher that is defined in 2007 report of the International Dry Eye Workshop and/or keratoconjunctival disorders, and a pharmaceutical composition comprising said drug. Also provided is a method for treating dry eye with a dry eye severity level 3 or higher that is defined in 2007 10 report of the International Dry Eye Workshop and/or keratoconjunctival disorders by using the aforesaid drug.