Methods for inducing orexin neurons and agent for treating narcolepsy or eating disorder

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专利权人:

发明人:

Kunio Shiota,Shintaro Yagi,Koji Hayakawa,Mitsuko Hirosawa-Takamori,Daisuke Arai,Keiji Hirabayashi

申请号：

US14224730

公开号：

US09480695B2

申请日:

2014.03.25

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The invention provides a method for producing an orexin neuron by culturing a pluripotent stem cell or a neural progenitor cell in the presence of N-acetyl-D-mannosamine and optionally in the presence of at least one inhibitor selected from the group consisting of a Sirtuin 1 inhibitor and an O-linked β-N-acetylglucosamine transferase inhibitor. The invention also provides a therapeutic agent for narcolepsy or eating disorders, such as anorexia, containing N-acetyl-D-mannosamine, which is based on the induction of orexin neuron in vivo.

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中国工程科技知识中心

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http://www.ckcest.cn/home/