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Polymorphs of 2 - (4 - (2 - (1 - isopropyl - 3 - methyl - 1h-1,2,4-triazole - 5 - yl) - 5.6 - dihidrobenzo [f] imidazo [1,2-d] [1,4] oxazepin - 9 - il) - 1H pyrazol-1-yl) - 2 - metilpropanamida, Production methods and Pharmaceutical uses of the same
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
申请号:
ARP140104667
公开号:
AR098762A1
申请日:
2014.12.15
申请国别(地区):
AR
年份:
2016
代理人:
摘要:
This application relates to Crystalline polymorphs of 2 - (4 - (2 - (1 - isopropyl - 3 - methyl - 1h-1,2,4-triazole - 5 - yl) - 5.6 - dihidrobenzo [f] imidazo [1,2-d] [1,4] oxazepin - 9 - yl) - 1H pyrazole - 1 - il) - 2 - (GDC metilpropanamida 0032, taselisib), Methods of use and processes for preparing the same.Claim 1: a non solvated Crystalline Polymorph of 2 - (4 - (2 - (1 - isopropyl - 3 - methyl - 1h-1,2,4-triazole - 5 - yl) - 5.6 - dihidrobenzo [f] imidazo [1,2-d] [1,4] oxazepin - 9 - yl) - 1H pyrazole - 1 - il) - 2 - metilpropanamida called the polymorphic Form b that shows a pattern of x-ray diffraction Peaks that have Expressed in characteristic 2 - Q Angles approximately 10.7, 14.0, 16.4, 18.6, 22.1, and 26.4.La presente solicitud se refiere a polimorfos cristalinos de 2-(4-(2-(1-isopropil-3-metil-1H-1,2,4-triazol-5-il)-5,6-dihidrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-il)-1H-pirazol-1-il)-2-metilpropanamida (GDC 0032, taselisib), a métodos de uso, y procesos para preparar los mismos. Reivindicación 1: Un polimorfo cristalino no solvatado de 2-(4-(2-(1-isopropil-3-metil-1H-1,2,4-triazol-5-il)-5,6-dihidrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-il)-1H-pirazol-1-il)-2-metilpropanamida denominado el polimorfo de Forma B que muestra un patrón de difracción de rayos X que tiene picos característicos expresados en ángulos 2-q a aproximadamente 10,7, 14,0, 16,4, 18,6, 22,1, y 26,4.
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中国工程科技知识中心
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