INSTITUT GUSTAVE-ROUSSY;UNIVERSITE PARIS DESCARTES;INSTITUT PASTEUR;CENTRE HOSPITALIER SAINTE ANNE PARIS
发明人:
Fabrice Bruno CHRETIEN,Raphael GAILLARD,Pierre ROCHETEAU,Olivier MIR
申请号：
US16669626
公开号：
US20200060999A1
申请日:
2019.10.31
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to the field of muscle regeneration, and more particularly to the replenishment of the in vivo muscle stem cells pool. It more specifically relates to a 5-hydroxytryptamine B1 receptor-stimulating agent, and to a composition comprising said agent, for use as i) a promoter of satellite cells self-renewal and/or differentiation, and/or ii) an agent preventing and/or inhibiting the satellite cells pool exhaustion. The invention further encompasses therapeutic and screening methods.
