MUTEINE, PROCEDE PERMETTANT DE PRODUIRE LADITE MUTEINE, GENE CODANT POUR LADITE MUTEINE, VECTEUR RECOMBINANT ET PLANTE PORTANT LEDIT GENE, PROCEDE DE REGULATION D'UNE QUANTITE D'ACIDE MEVALONIQUE PRODUITE ET D'UNE QUANTITE D'ISOPRENOIDE PRODUIT, PROCEDE PERMETTANT DE REGULER L'ACTIVITE 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE
Provided is a mutein having mutations of specific amino acid residues of HMGR, which is a rate-limiting enzyme of isoprene monomer biosynthesis in the polyisoprenoid biosynthetic pathway. The present invention relates to a mutein in which at least one amino acid residue selected from the group consisting of positions 91, 225, 257, 287, 339, 411, 470, 509, and 574 and amino acid residues of positions corresponding to these in Arabidopsis thaliana 3-hydroxy-3-methylglutaryl-CoA reductase shown by SEQ ID NO: 1 have been deleted or substituted by another amino acid residue in 3-hydroxy-3-methylglutaryl-CoA reductase.
