The present invention provides a multilayer sheet that can be used in vivo or in an environment in which moisture is adhered, an integrated sheet including the multilayer sheet and a base material, and methods for producing the same. According to the present invention, there is provided a multilayer sheet in which one or more layers from each of a layer (A) composed of sparingly water-soluble polymer and a fiber layer (B) composed of water-soluble polymer are laminated, and at least one of outermost layers is the above-described layer (A) composed of sparingly water-soluble polymer. In the multilayer sheet of the present invention, the time taken from dropping of water onto a surface of the outermost layer of the above-described layer (A) composed of sparingly water-soluble polymer to dissolution of the other outermost layer is from 10 seconds to 5 minutes.
