The present invention provides the method for the antibody preparation to reduce from the mixture production HCP comprising antibody and at least one host cell proteins matter (HCP), the method includes ion-exchange steps, the first ion exchange material is wherein applied the mixture to, the antibody preparation reduced thus to obtain HCP.本發明提供用以從包含抗體和至少一種宿主細胞蛋白質(HCP)的混合物生産HCP降低的抗體製品的方法,所述方法包括離子交換步驟,其中將該混合物施加到第一離子交換材料,由此獲得HCP降低的抗體製品。