Alan Verkman;Luis J. V. Galietta;Nicoletta Pedemonte
发明人:
Alan Verkman,Nicoletta Pedemonte,Luis J. V. Galietta
申请号：
US11908591
公开号：
US08143295B2
申请日:
2006.03.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides compositions, pharmaceutical preparations and methods for correcting cellular processing (e.g., folding, trafficking, or post-translational modification) of a mutant-cystic fibrosis transmembrane conductance regulator protein (e.g., ΔF508 CFTR) that are useful for the treatment of cystic fibrosis (CF). The compositions and pharmaceutical preparations of the invention may comprise one or more aminobenzothiazole-containing compounds, aminoarylthiazole-containing compounds, quinazolinylaminopyrimidinone-containing compounds, bisaminomethylbithiazole-containing compounds, or phenylaminoquino-line-containing compounds of the invention, or an analog or derivative thereof.
