PROBLEM TO BE SOLVED: To provide a fluid ejection device appropriate for controlling ejection operation of fluid in response to a contact state between an ejection object and an ejection tip, and further to provide a driving method of the fluid ejection device and a surgical instrument.SOLUTION: A fluid ejection device 1 is constituted so as to include: a fluid chamber 501 of which a volume can be changed a volume change section 405 for changing the volume of the fluid chamber 501 a connection flow passage tube 200 for transmitting a pulse from the fluid chamber 501 to a fluid ejection opening 212 of a nozzle 211 positioned at a tip a pump 20 for supplying fluid a first electrode 50 causing the nozzle 211 to serve as a first contact portion 50a a second electrode 51 having a second contact portion 51a capable of being adhered to an ejection object a current-carrying determination section 30b for determining current carrying states of the first and second electrodes 50 and 51 and a drive section 30 for driving the volume change section 405. Further, the drive section 30 controls the volume change section 405 so as to allow the volume change section 405 to operate at the time of the current carrying state and so as not to allow the volume change section 405 to operate at the time of a non-current carrying state.COPYRIGHT: (C)2015,JPO&INPIT【課題】噴射対象物と噴射先端との接触状態に応じて流体の噴射動作を制御するのに好適な流体噴射装置、流体噴射装置の駆動方法及び手術用器具を提供する。【解決手段】流体噴射装置1を、容積が変更可能な流体室501と、流体室501の容積を変更する容積変更部405と、流体室501からの脈動を先端のノズル211の流体噴射開口部212に伝達する接続流路管200と、流体を供給するポンプ20と、ノズル211を第1の接触部50aとした第1の電極50と、噴射対象物に貼付可能な第2の接触部51aを有する第2の電極51と、第1及び第2の電極50及び51の通電状態を判定する通電判定部30bと、容積変更部405を駆動する駆動部30とを含む構成とした。そして、駆動部30は、通電状態のときに、容積変更部405を動作可能に制御し、通電していない状態のときに、容積変更部405を動作しないように制御する。【選択図】図1