БАУДНЕР Барбара (IT),СКИБИНСКИ Дэвид А.Г. (SG),СИНГХ Манмохан (US),О'ХЕЙГАН Дерек (US),ОХЕЙГАН Дерек (US)
申请号：
RU2013144207/15
公开号：
RU2013144207A
申请日:
2012.03.02
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. An immunogenic composition in a single dose form for administration to a patient containing (i) diphtheria toxoid, tetanus toxoid and acellular pertussis antigen containing pertussis toxoid, (ii) aluminum salt adjuvant, where the amount of Al in a single dose is less than 0.2 mg, and (iii) a TLR agonist adsorbed on an adjuvant of an aluminum salt. 2. An immunogenic composition comprising (i) diphtheria toxoid, tetanus toxoid and pertussis toxoid, (ii) an aluminum salt adjuvant where the concentration of Al is less than 0.4 mg / ml, and (iii) a TLR agonist adsorbed on an aluminum salt adjuvant. 3. The composition according to claim 1 or 2, wherein the composition comprises one or more of (i) a Hib conjugate, (ii) a surface antigen of hepatitis B virus and / or (iii) an antigen of inactivated polio virus. An immunogenic composition comprising (i) an adjuvant aluminum salt, (ii) a low dose of each of diphtheria toxoid, tetanus toxoid and pertussis toxoid； and (iii) a TLR agonist adsorbed on an adjuvant of an aluminum salt. 5. A single dose immunogenic composition for administration to a patient containing (i) a low dose of each of diphtheria toxoid, tetanus toxoid and pertussis toxoid, (ii) an aluminum salt adjuvant, where the amount of Al in a single dose is less than 0.2 mg, and (iii) TLR agonist adsorbed on adjuvant of aluminum salt. 6. An immunogenic composition comprising (i) a low dose of each of diphtheria toxoid, tetanus toxoid and pertussis toxoid, (ii) an aluminum salt adjuvant, where the concentration of Al is less than 0.4 mg / ml, and (iii) a TLR agonist adsorbed on an aluminum salt adjuvant .7. The composition according to any one of paragraphs. 4-6, where the composition contains ≤? 8 Lf / ml diphtheria toxoid. 8. The composition according to any one of paragraphs. 4-6, where the composition1. Иммуногенная композиция в форме разовой дозы для введения пациенту, содержащая (i) токсоид дифтерии, токсоид столбняка и бесклеточный антиген коклюша, содержащи
