A laser irradiation system, method, and apparatus that can generate optical energy at a specific or a range of wavelengths, power levels, and beam profiles, among others, to treat acute or chronic inflammation, wounds, and autoimmune deficiency conditions without ablating the target tissue or surrounding tissue. In one aspect, the light beam of the laser irradiation system, method, and apparatus can stimulate photoreceptors within a cell, thereby initiating a cascade of secondary cellular metabolic effects and normalizing cellular activity towards homeostasis, among other advantages.