The present invention provides a polyploid adeno-associated virus (AAV)capsid,wherein the capsid comprises capsid protein VP1, wherein said capsid proteinVP1 is fromone or more than one first AAV serotype, wherein said capsid protein VP2 isfrom one or more thanone first AAV serotype and capsid protein VP3, wherein said capsid protein VP3is from one ormore than one second AAV serotype and wherein at least one of said first AAVserotype isdifferent from at least one of said second AAV serotype and is different fromat least one ofsaid third AAV serotype, in any combination.