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METHODS OF INHIBITING MUSCLE ATROPHY
专利权人:
发明人:
申请号:
HK14110271.3
公开号:
HK1196775A
申请日:
2014.10.15
申请国别(地区):
HK
年份:
2014
代理人:
摘要:
In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. The disclosed compounds can treat muscle atrophy when administered in an effective amount to an animal, such as a mammal, fish or bird. For example, human. Also disclosed in a method of lowering blood glucose in an animal by administering ursolic acid or ursolic acid analogs, such as betulininc acid analogs, and narigenin analogs, such as naringenin, in an effective amount to an animal. Also disclosed in a method of lowering blood glucose in an animal by administering ungerine/hippeastrine analogs, such as hippeastrine, in an effective amount to an animal. The disclosed compounds can also promote muscle health, promote normal muscle function, and/or promote healthy aging muscles by providing to a subject in need thereof an effective amount of a disclosed compound.Dans un aspect, linvention concerne des méthodes de traitement dune atrophie musculaire par lapport à un animal en ayant besoin dune quantité efficace dun composé. Le composé peut moduler les niveaux dexpression dARNm multiple dune signature datrophie musculaire. Cet abrégé est destiné à être un outil de balayage dans des objectifs de recherche dans cette technique particulière et nest pas destiné à limiter la présente invention. Les composés selon invention permettent de traiter latrophie musculaire lorsquils sont administrés en quantité efficace chez un animal, notamment un mammifère, un poisson ou un oiseau. Par exemple, un humain. Linvention concerne également un procédé permettant dabaisser la glycémie chez un animal par ladministration dacide ursolique ou danalogues de lacide ursolique, notamment des analo
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