Bart Lambrecht;Jonathan M. Austyn;Dermot M. O'Hare
发明人:
Jonathan M. Austyn,Dermot M. O'Hare,Bart Lambrecht,Dermot M. OHare
申请号：
US13640213
公开号：
US20130064795A1
申请日:
2011.04.11
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides a layered double hydroxide compound for use in modulating an immune response to an antigen, and an immune modulator composition comprising the layered double hydroxide and an antigen. The compound is of formula (I), (II), or (III)[MIMIII2(OH)6]+[An−1/n] (I)[MII(1−x)MIIIx(OH)2]x+[An−x/n] (II)[MIIMIII4(OH)12][An−2/n] (III)in which MI is Li+, MII is a divalent metal cation or a mixture of two or more divalent metal cations, MIII is a trivalent metal cation or a mixture of two or more trivalent metal cations, or a mixture of one or more trivalent metal cation with one or more quadravalent metal cation, x is from ⅕ to ⅓, and A is an interlayer anion having a charge n, wherein optionally some or all of the interlayer anion A may be replaced by one or biologically active agent and/or one or more antigen, and wherein A is selected from conjugate bases of acids having a pKa of 1 or higher, except for in LDHs of formula (II) when MII comprises Ca2+ and in LDHs of formula (I), wherein A is selected from conjugate bases of acids having a pKa of −4 or higher.
