1. A method of producing tiotropium bromide particles with an average size of from about 100 nm to 10,000 nm, comprising: a) dissolving tiotropium bromide in an organic solvent to obtain a liquid solution； b) forming a stream of said liquid solution, preferably under pressure, which is mixed with an anti-solvent stream preferably under pressure； and c) where the mixed stream is sprayed from the outlet of the spray nozzle into a vessel to obtain a precipitate. 2. The method of claim 1, wherein said tiotropium bromide particles have an average size of from about 100 nm to about 3000 nm. The method according to PP. 1 or 2, where these particles are amorphous particles of tiotropium bromide. 4. The method according to PP. 1 or 2, where these particles are crystalline particles of tiotropium bromide. 5. A method according to claim 1, wherein the mixed stream that is sprayed into the vessel is a suspension. The method according to claim 5, wherein the suspension is stirred for a predetermined period of time, after which it is filtered and dried to obtain an easily free flowing powder. The method of claim 6, wherein said readily bulk powder comprises low density tiotropium bromide particle powder. The method of claim 1, wherein said organic solvent is 2,2,2-trifluoroethanol or dimethyl sulfoxide. The method of claim 1, wherein said organic solvent is dimethyl sulfoxide, dimethylacetamide, N-methyl pyrrolidone, methanol, water, acetone, acetonitrile, n-propanol, isopropanol, PEG400 or 2,2,2-trifluoroethanol, or a mixture of any of the listed solvents. 10. The method of claim 1, wherein said anti-solvent is supercritical CO, methyl tert-butyl ether or ethyl acetate, or a mixture of methyl tert-butyl ether and ethyl acetate. The method according to p.1. Способ получения частиц тиотропия бромида со средним размером примерно от 100 нм до 10000 нм, включающий:a) растворение тиотропия бромида в органическом растворителе с получением жидкого раствора；b) формирование потока указанн
