A system and method for measuring a depth or length of area of interest a telemedicine patient, comprising: a first image capturing device that captures a two-dimensional (2D) image or video of a region of interest of a patient； a second image capturing device that generates a three-dimensional (3D) point cloud of the region of interest of the patient； a rendering system that processes a unified view for both the first and second image capturing devices where the 2D image and 3D point cloud are generated and registered； and a remote measurement processing system that determines a depth or length between two points selected from the 2D image of the region of interest by identifying associated points in the 3D point cloud and performing a measurement using the identified associated points in the 3D point cloud.
