ZHANG ZHUMING,GRAVES BRADFORD JAMES,JIANG NAN,ZHANG JING,DING QINGJIE,BARTKOVITZ DAVID JOSEPH,CHU XIN-JIE
申请号：
NZ60002410
公开号：
NZ600024A
申请日:
2010.11.29
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Provided herein are compounds of the formula (I) or (II) wherein X, Y and R1 to R8 are described herein along with the enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as antagonist of interactions between p53 and MDM2 which is useful in the treatment of cancer. In one embodiment the compound is (2&rsquo；S,3&rsquo；R,4&rsquo；S,5&rsquo；R)-6-chloro-4&rsquo；-(3-chloro-2-fluoro-phenyl)-2&rsquo；-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3&rsquo；-pyrrolidine]-5&rsquo；-carboxylic acid [4-(2-hydroxy-ethoxy)-phenyl]-amide.
